Is chiropractic an effective treatment in infantile colic?

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  1. Stephen Hughes1,
  2. Jennifer Boltontwo
  1. anePaediatric SpR, Northwick Park Hospital, Harrow
  2. 2Manager of Research, Anglo-European Higher of Chiropractic, Bournemouth BH5 2DF

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Mrs A presents with her 6 week old babe, complaining of his excessive and uncontrollable crying behaviour, particularly in the evening and at night. The child is otherwise salubrious, thriving, and has a normal weight gain. Following questions regarding the blueprint of crying, and associated signs, it is apparent that the child is exhibiting typical colic behaviour. At that place are clear signs that the continual and excessive crying behaviour is impairing the mother–kid relationship, and you consider the child might be at increased run a risk of harm (or neglect). In discussing the treatment options, Mrs A tells you that her chiropractor has offered to treat her baby for the excessive crying behaviour. She herself has been treated by this chiropractor in the past for dorsum pain, and it is obvious she has considerable confidence in him. She asks your advice.

Structured clinical question

In an otherwise healthy 6 week one-time baby with typical colicky hurting [patient], is chiropractic [intervention] effective in reducing the severity of the colic, or the length of time spent crying [outcome]?

Search strategy and outcome

Medline: "colic" AND "chiropractic" AND filter "therapy"—three articles; ((colic AND chiropractic) AND (randomized controlled trial [PTYP] OR drug therapy [SH] OR therapeutic use [SH:NOEXP] OR random* [Discussion]))—two articles, (both RCTs). Hand searching—abstract (Mercer and Nook). See table 3.

View this table:

Commentary

The early prospective study is the first documented evidence to indicate a possible benign effect of chiropractic intervention in colic, and equally such highlights the demand for futurity RCTs. The RCT reported by Mercer and Nook is merely published in abstract form, and the lack of detail prevents scrutiny of its methodology and data analysis. It is therefore not included in the best evidence available for the effectiveness of chiropractic for colic.

Both RCTs (Wiberg et al and Olafsdottir et al) were comparable in pattern and of good quality. The major difference was in the blinding of parents who completed the crying diary (and the symptom improvement score) and therefore in the reduction of parents' bias. This strengthens the trial by Olafsdottir et al, and their determination that chiropractic offers no greater efficacy in treating infantile colic than placebo. On the other hand, the positive effects of spinal manipulation reported by Wiberg et al are almost certainly not as benign as they would have been had an intention to treat analysis been carried out. All nine dropouts in the dimethicone group were every bit a upshot of a worsening of symptoms (and non parents' bias confronting medication). In that location were no dropouts in the spinal manipulation group. The first written report is a study of effectiveness—information technology is pragmatic. Parents taking their child to a chiropractor clearly written report a meaning comeback. By eliminating parental bias, the 2d study is an efficacy written report of chiropractic intervention. Chiropractic itself does not appear to exist efficacious. An culling explanation for these disparate results is postulated by Grunnet-Nilsson and Wiberg who hypothesise a dose–response miracle. In the trial by Olafsdottir et al, a treatment protocol of a maximum of three sessions of spinal manipulation was used over eight days, whereas the report by Wiberg et al relied on the clinical sentence of the chiropractor. All infants received three to five sessions of chiropractic over a 14 day menses (64% greater than three). Again this reflects the pragmatic nature of the study past Wiberg et al, and the investigation of effectiveness as opposed to efficacy of a treatment intervention.

▸ CLINICAL Lesser LINE

  • The evidence suggests that chiropractic has no benefit over placebo in the treatment of infantile colic. However, in that location is skillful evidence that taking a colicky babe to a chiropractor will upshot in fewer reported hours of colic by the parents.

  • In this clinical scenario where the family unit is under significant strain, where the infant may be at risk of harm and possible long term repercussions, where there are limited alternative effective interventions, and where the mother has confidence in a chiropractor from other experiences, the communication is to seek chiropractic treatment.

References

Supplementary materials


  • Table 3

    Commendation Study group Study type (level of evidence) Consequence Key results Comments

    Klougart et al (1989) 316 otherwise good for you infants (age 2�xvi weeks) with symptoms of colic according to well divers criteria, all treated with chiropractic spinal manipulation. Primary evaluation after two weeks of treatment (average of 3 handling visits). Number of dropouts = 17 Prospective unmarried cohort observational study (level 2b) Daily hours of crying using diary completed past parents Hateful no. of daily hours crying over 2 days before treatment (retrospective approximate): v.2. At day 1: ii.5, and at day 14: 0.65 (74% reduction). Unclear whether infants had been treated on day ane Lack of blinding introduces considerable bias. Lack of randomisation and a control group prevents estimates of a placebo effect or natural course of the condition, which is known to meliorate with age. The study is however important because of the large number of infants recruited
    Symptom improvement score estimated by parents At 24-hour interval xiv; half dozen% of sample no change or worse, 34% improved, 60% stopped colic symptoms
    Mercer and Nook (1999) 30 infants (0�viii weeks) suffering from infantile colic diagnosed by a paediatrician (criteria unclear). 15 infants treated by chiropractic spinal manipulation (experimental); fifteen infants treated with a not-functional, de-tuned ultrasound machine (placebo). In both groups, a maximum of half-dozen treatments over two weeks. No information given on dropouts RCT (level 1b) Unmarried blinded written report. Randomisation unclear Subjective response to treatment by parents before treatment and at each subsequent consultation. Outcomes not defined Statistically significant difference (no data given) in response to treatment between 2 groups (assumed benign in experimental group). Complete resolution of symptoms in 93% of infants in (assumed) experimental group. No comparative information for placebo grouping This study was reported in abstract grade. The pocket-sized sample group without well defined inclusion data and the lack of detail in methodology and recorded data seriously undermines the contribution of this written report to the prove base. Even so, it is reported for completeness, and does back up the suggestion of a benign consequence of chiropractic
    Wiberg et al (1999) l considerately healthy infants (age 2�10 weeks) with well divers colic. 25 treated with chiropractic spinal manipulation for ii weeks (mean three.8 treatments) and sixteen with dimethicone for two weeks (9 dropouts) RCT (level 1b) Single blinded study. Method of randomisation unclear Daily hours of crying using diary (completed past parents) At eight�11 days, hateful modify in no. of hours crying: -ane.0 (SE 0.4) dimethicone; -2.seven (0.3) spinal manipulation (p=0.004) Parents reporting upshot knew the intervention. Dimethicone has been shown to exist no better than placebo treatments. No follow upward flow subsequently treatment period so unsure whether observed effect is maintained
    Olafsdottir et al (2001) 100 colicky infants (age three�ix weeks) meeting strict entry criteria. fifty treated with chiropractic spinal manipulation for 3 visits (over viii days) and 50 given placebo treatment (holding). (9 infants excluded (failure to meet entry criteria) and 5 drop outs leaving 86 completing trial) RCT (level 1b) Double blinded study. Randomisation past sealed envelopes Daily hours of crying using diary (completed by parents) At third (terminal) visit (day eight), mean no. of hours crying: 3.one (SD ii.7) spinal manipulation; 3.one (SD two.7) placebo (p=0.982) No results given for follow up period afterwards treatment finished. No CI or RR given in spite of reference to them in the methods
    Symptom improvement score 8�14 days after concluding visit (completed by parents) No difference in symptom scores between spinal manipulation and placebo (p=0.743). NNT = x (95% CI iii to{infty}); NNH (95%CI 9 to{infty}) No results given for improvement later on visits i and 2y

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